HCN4 current during human sinoatrial node-like action potentials
نویسندگان
چکیده
منابع مشابه
Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes.
The present study investigated the electropharmacological effects of a traditional Chinese herbal drug, berberine, on the spontaneous activity of sinoatrial nodes (SANs) of the rabbit heart and on human hyperpolarization-activated cyclic nucleotide-gated 4 (hHCN4) channels, which are heterologously expressed in xenopus oocytes, and which contribute to pacemaker currents (Ifs). A standard microe...
متن کاملPacemaker current (I(f)) in the human sinoatrial node.
AIMS Animal studies revealed that the hyperpolarization-activated pacemaker current, I(f), contributes to action potential (AP) generation in sinoatrial node (SAN) and significantly determines heart rate. I(f) is becoming a novel therapy target to modulate heart rate. Yet, no studies have demonstrated that I(f) is functionally present and contributes to pacemaking in human SAN. We aimed to stud...
متن کاملIs sodium current present in human sinoatrial node cells?
Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform patch-clamp experiments on single pacemaker cells isolated from a human sinoatri...
متن کاملMorphology of mouse sinoatrial node and its expression of NF-160 and HCN4.
OBJECTIVE To explore the morphology and cell component of the sinoatrial node in adult mice and to observe the expressions of neurofilament protein (NF-160) and hyperpolarization-activated cyclic nucleotide regulation of cation channel 4 (HCN4) in sinus node cells. METHODS The right and left atria were collected from 10 adult mice. After paraffin embedding and serial section, these sections u...
متن کاملA mathematical model of action potentials of mouse sinoatrial node cells with molecular bases
Genetically modified mice are popular experimental models for studying the molecular bases and mechanisms of cardiac arrhythmia. A postgenome challenge is to classify the functional roles of genes in cardiac function. To unveil the functional role of various genetic isoforms of ion channels in generating cardiac pacemaking action potentials (APs), a mathematical model for spontaneous APs of mou...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2021
ISSN: 0079-6107
DOI: 10.1016/j.pbiomolbio.2021.05.006